A recent bottleneck of Y chromosome diversity coincides with a global change in culture.

Maru Mormina, Monika Karmin, Toomas Kivisild

Research output: Contribution to journalArticleResearchpeer-review

4 Downloads (Pure)

Abstract

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosomesequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-Africanfounder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Original languageEnglish
Pages (from-to)459-466
JournalGenome Research
Volume25
Publication statusPublished - 13 Mar 2015

Keywords

  • mitochondrial DNA
  • Africa
  • Article
  • cultural factor
  • DNA determination
  • female
  • founder effect
  • gender
  • gene sequence
  • genetic variability
  • global change
  • haplogroup
  • human
  • male
  • Pacific islands
  • priority journal
  • reproductive success
  • Y chromosome

Cite this

Mormina, M., Karmin, M., & Kivisild, T. (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. 25, 459-466.
Mormina, Maru ; Karmin, Monika ; Kivisild, Toomas. / A recent bottleneck of Y chromosome diversity coincides with a global change in culture. 2015 ; Vol. 25. pp. 459-466.
@article{1ff916dbbe2e4d2497560668402388ce,
title = "A recent bottleneck of Y chromosome diversity coincides with a global change in culture.",
abstract = "It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosomesequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95{\%} CI 192–307) kya and detect a cluster of major non-Africanfounder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.",
keywords = "mitochondrial DNA, Africa, Article, cultural factor, DNA determination, female, founder effect, gender, gene sequence, genetic variability, global change, haplogroup, human, male, Pacific islands, priority journal, reproductive success, Y chromosome",
author = "Maru Mormina and Monika Karmin and Toomas Kivisild",
year = "2015",
month = "3",
day = "13",
language = "English",
volume = "25",
pages = "459--466",

}

Mormina, M, Karmin, M & Kivisild, T 2015, 'A recent bottleneck of Y chromosome diversity coincides with a global change in culture.' vol. 25, pp. 459-466.

A recent bottleneck of Y chromosome diversity coincides with a global change in culture. / Mormina, Maru; Karmin, Monika; Kivisild, Toomas.

Vol. 25, 13.03.2015, p. 459-466.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A recent bottleneck of Y chromosome diversity coincides with a global change in culture.

AU - Mormina, Maru

AU - Karmin, Monika

AU - Kivisild, Toomas

PY - 2015/3/13

Y1 - 2015/3/13

N2 - It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosomesequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-Africanfounder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

AB - It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosomesequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-Africanfounder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

KW - mitochondrial DNA

KW - Africa

KW - Article

KW - cultural factor

KW - DNA determination

KW - female

KW - founder effect

KW - gender

KW - gene sequence

KW - genetic variability

KW - global change

KW - haplogroup

KW - human

KW - male

KW - Pacific islands

KW - priority journal

KW - reproductive success

KW - Y chromosome

M3 - Article

VL - 25

SP - 459

EP - 466

ER -