TY - JOUR
T1 - Characterising nutrition status in a regional cohort of children with primary ciliary dyskinesia
AU - Marino, Luise V
AU - Harris, Amanda
AU - Johnstone, Carolyn
AU - Friend, Amanda
AU - Keenan, Victoria
AU - Wilkins, Hannah
AU - Lucas, Jane
AU - Calder, Philip
AU - Walker, Woolf
PY - 2018/11/19
Y1 - 2018/11/19
N2 - Introduction: Primary ciliary dyskinesia (PCD) is a rare, heterogeneous genetic disorder where impaired mucociliary clearance is caused by dysfunctional motile cilia. There is limited characterisation of the nutritional status of children with PCD but one recent paper found that lower body mass index (BMI) was associated with worse lung function (FEV1). Bioimpedance spectroscopy (BIS) has been used to identify patients at risk of needing nutritional intervention but this has not been assessed in PCD patients. Aim To assess, in depth, the nutritional status of children with PCD. Methods: All children (n=40) with PCD, -2 z scores (mean (SD) -0.49 z scores (±1.1) vs. 0.2 a score (±0.7), p=0.05. Significant differences were seen in BIS measurements (bioelectrical phase angle 500) in children with a fat free mass index -2 z scores (p=0.002), these patients would not have been identified as at nutritional risk by BMI alone. PCD patients had a higher incidence of Vitamin D insufficiency (
AB - Introduction: Primary ciliary dyskinesia (PCD) is a rare, heterogeneous genetic disorder where impaired mucociliary clearance is caused by dysfunctional motile cilia. There is limited characterisation of the nutritional status of children with PCD but one recent paper found that lower body mass index (BMI) was associated with worse lung function (FEV1). Bioimpedance spectroscopy (BIS) has been used to identify patients at risk of needing nutritional intervention but this has not been assessed in PCD patients. Aim To assess, in depth, the nutritional status of children with PCD. Methods: All children (n=40) with PCD, -2 z scores (mean (SD) -0.49 z scores (±1.1) vs. 0.2 a score (±0.7), p=0.05. Significant differences were seen in BIS measurements (bioelectrical phase angle 500) in children with a fat free mass index -2 z scores (p=0.002), these patients would not have been identified as at nutritional risk by BMI alone. PCD patients had a higher incidence of Vitamin D insufficiency (
UR - https://www.mendeley.com/catalogue/6f571cef-f11e-3ced-bdba-3812bf379ba6/
UR - https://www.mendeley.com/catalogue/6f571cef-f11e-3ced-bdba-3812bf379ba6/
U2 - 10.1183/13993003.congress-2018.pa4670
DO - 10.1183/13993003.congress-2018.pa4670
M3 - Article
VL - 52
JO - European Respiratory Journal, Supplement
JF - European Respiratory Journal, Supplement
SN - 0904-1850
IS - S62
ER -