Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy

Adam Lucero, Gifty Addae, Wayne Lawrence, Beemnet Neway, Daniel Creduer, James Faulkner, David Rowlands, Lee Stoner

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Abstract

Near-infrared spectroscopy (NIRS), coupled with rapid venous and arterial occlusions, can be used for the non-invasive estimation of resting local skeletal muscle blood flow (mBF) and oxygen consumption (math formula), respectively. However, the day-to-day reliability of mBF and math formula responses to stressors such as incremental dynamic exercise has not been established. The aim of this study was to determine the reliability of NIRS-derived mBF and math formula responses from incremental dynamic exercise. Measurements of mBF and math formula were collected in the vastus lateralis of 12 healthy, physically active adults [seven men and five women; 25 (SD 6) years old] during three non-consecutive visits within 10 days. After 10 min rest, participants performed 3 min of rhythmic isotonic knee extension (one extension every 4 s) at 5, 10, 15, 20, 25 and 30% of maximal voluntary contraction (MVC), before four venous occlusions and then two arterial occlusions. The mBF and math formula increased proportionally with intensity [from 0.55 to 7.68 ml min−1 (100 ml)−1 and from 0.05 to 1.86 ml O2 min−1 (100 g)−1, respectively] up to 25% MVC, where they began to plateau at 30% MVC. Moreover, an mBF/math formula muscle oxygen consumption ratio of ∼5 was consistent for all exercise stages. The intraclass correlation coefficient for mBF indicated high to very high reliability for 10–30% MVC (0.82–0.9). There was very high reliability for math formula across all exercise stages (intraclass correlation coefficient 0.91–0.96). In conclusion, NIRS can reliably assess muscle blood flow and oxygen consumption responses to low- to moderate-intensity exercise, meriting potential applications in clinical diagnosis and therapeutic assessment.
Original languageEnglish
Pages (from-to)1-11
JournalExperimental Physiology
Volume00
Issue number000
Publication statusPublished - 22 Nov 2017

Keywords

  • Near-infrared spectroscopy
  • blood flow
  • oxygen consumption
  • exercise.

Cite this

Lucero, A., Addae, G., Lawrence, W., Neway, B., Creduer, D., Faulkner, J., ... Stoner, L. (2017). Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy. Experimental Physiology, 00(000), 1-11.
Lucero, Adam ; Addae, Gifty ; Lawrence, Wayne ; Neway, Beemnet ; Creduer, Daniel ; Faulkner, James ; Rowlands, David ; Stoner, Lee. / Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy. In: Experimental Physiology. 2017 ; Vol. 00, No. 000. pp. 1-11.
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abstract = "Near-infrared spectroscopy (NIRS), coupled with rapid venous and arterial occlusions, can be used for the non-invasive estimation of resting local skeletal muscle blood flow (mBF) and oxygen consumption (math formula), respectively. However, the day-to-day reliability of mBF and math formula responses to stressors such as incremental dynamic exercise has not been established. The aim of this study was to determine the reliability of NIRS-derived mBF and math formula responses from incremental dynamic exercise. Measurements of mBF and math formula were collected in the vastus lateralis of 12 healthy, physically active adults [seven men and five women; 25 (SD 6) years old] during three non-consecutive visits within 10 days. After 10 min rest, participants performed 3 min of rhythmic isotonic knee extension (one extension every 4 s) at 5, 10, 15, 20, 25 and 30{\%} of maximal voluntary contraction (MVC), before four venous occlusions and then two arterial occlusions. The mBF and math formula increased proportionally with intensity [from 0.55 to 7.68 ml min−1 (100 ml)−1 and from 0.05 to 1.86 ml O2 min−1 (100 g)−1, respectively] up to 25{\%} MVC, where they began to plateau at 30{\%} MVC. Moreover, an mBF/math formula muscle oxygen consumption ratio of ∼5 was consistent for all exercise stages. The intraclass correlation coefficient for mBF indicated high to very high reliability for 10–30{\%} MVC (0.82–0.9). There was very high reliability for math formula across all exercise stages (intraclass correlation coefficient 0.91–0.96). In conclusion, NIRS can reliably assess muscle blood flow and oxygen consumption responses to low- to moderate-intensity exercise, meriting potential applications in clinical diagnosis and therapeutic assessment.",
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Lucero, A, Addae, G, Lawrence, W, Neway, B, Creduer, D, Faulkner, J, Rowlands, D & Stoner, L 2017, 'Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy', Experimental Physiology, vol. 00, no. 000, pp. 1-11.

Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy. / Lucero, Adam; Addae, Gifty; Lawrence, Wayne; Neway, Beemnet; Creduer, Daniel; Faulkner, James; Rowlands, David; Stoner, Lee.

In: Experimental Physiology, Vol. 00, No. 000, 22.11.2017, p. 1-11.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lucero, Adam

AU - Addae, Gifty

AU - Lawrence, Wayne

AU - Neway, Beemnet

AU - Creduer, Daniel

AU - Faulkner, James

AU - Rowlands, David

AU - Stoner, Lee

PY - 2017/11/22

Y1 - 2017/11/22

N2 - Near-infrared spectroscopy (NIRS), coupled with rapid venous and arterial occlusions, can be used for the non-invasive estimation of resting local skeletal muscle blood flow (mBF) and oxygen consumption (math formula), respectively. However, the day-to-day reliability of mBF and math formula responses to stressors such as incremental dynamic exercise has not been established. The aim of this study was to determine the reliability of NIRS-derived mBF and math formula responses from incremental dynamic exercise. Measurements of mBF and math formula were collected in the vastus lateralis of 12 healthy, physically active adults [seven men and five women; 25 (SD 6) years old] during three non-consecutive visits within 10 days. After 10 min rest, participants performed 3 min of rhythmic isotonic knee extension (one extension every 4 s) at 5, 10, 15, 20, 25 and 30% of maximal voluntary contraction (MVC), before four venous occlusions and then two arterial occlusions. The mBF and math formula increased proportionally with intensity [from 0.55 to 7.68 ml min−1 (100 ml)−1 and from 0.05 to 1.86 ml O2 min−1 (100 g)−1, respectively] up to 25% MVC, where they began to plateau at 30% MVC. Moreover, an mBF/math formula muscle oxygen consumption ratio of ∼5 was consistent for all exercise stages. The intraclass correlation coefficient for mBF indicated high to very high reliability for 10–30% MVC (0.82–0.9). There was very high reliability for math formula across all exercise stages (intraclass correlation coefficient 0.91–0.96). In conclusion, NIRS can reliably assess muscle blood flow and oxygen consumption responses to low- to moderate-intensity exercise, meriting potential applications in clinical diagnosis and therapeutic assessment.

AB - Near-infrared spectroscopy (NIRS), coupled with rapid venous and arterial occlusions, can be used for the non-invasive estimation of resting local skeletal muscle blood flow (mBF) and oxygen consumption (math formula), respectively. However, the day-to-day reliability of mBF and math formula responses to stressors such as incremental dynamic exercise has not been established. The aim of this study was to determine the reliability of NIRS-derived mBF and math formula responses from incremental dynamic exercise. Measurements of mBF and math formula were collected in the vastus lateralis of 12 healthy, physically active adults [seven men and five women; 25 (SD 6) years old] during three non-consecutive visits within 10 days. After 10 min rest, participants performed 3 min of rhythmic isotonic knee extension (one extension every 4 s) at 5, 10, 15, 20, 25 and 30% of maximal voluntary contraction (MVC), before four venous occlusions and then two arterial occlusions. The mBF and math formula increased proportionally with intensity [from 0.55 to 7.68 ml min−1 (100 ml)−1 and from 0.05 to 1.86 ml O2 min−1 (100 g)−1, respectively] up to 25% MVC, where they began to plateau at 30% MVC. Moreover, an mBF/math formula muscle oxygen consumption ratio of ∼5 was consistent for all exercise stages. The intraclass correlation coefficient for mBF indicated high to very high reliability for 10–30% MVC (0.82–0.9). There was very high reliability for math formula across all exercise stages (intraclass correlation coefficient 0.91–0.96). In conclusion, NIRS can reliably assess muscle blood flow and oxygen consumption responses to low- to moderate-intensity exercise, meriting potential applications in clinical diagnosis and therapeutic assessment.

KW - Near-infrared spectroscopy

KW - blood flow

KW - oxygen consumption

KW - exercise.

M3 - Article

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Lucero A, Addae G, Lawrence W, Neway B, Creduer D, Faulkner J et al. Reliability of Muscle Blood Flow and Oxygen Consumption Response from Exercise Using Near-infrared Spectroscopy. Experimental Physiology. 2017 Nov 22;00(000):1-11.