TY - JOUR
T1 - Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
AU - Johnstone, Nicola
AU - Milesi, Chiara
AU - Burn, Olivia
AU - van den Bogert, Bartholomeus
AU - Nauta, Arjen
AU - Hart, Kathryn
AU - Sowden, Paul
AU - Burnet, Philip
AU - Cohen Kadosh, Kathrin
N1 - Funding Information:
This research was supported by faculty research fund from the Faculty of Health and Medical Sciences, University of Surrey, UK to KCK. FrieslandCampina provided the galacto-oligosaccharides (GOS, prebiotics) used in this study. This manuscript is available on the preprint server medrxiv at https://doi.org/10.1101/19011403.
PY - 2021/4/15
Y1 - 2021/4/15
N2 - Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
AB - Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
UR - http://www.scopus.com/inward/record.url?scp=85104401422&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/233522bd-041e-341a-98a4-811c12b0ee46/
U2 - 10.1038/s41598-021-87865-w
DO - 10.1038/s41598-021-87865-w
M3 - Article
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 8302
ER -