Hemodynamic variability and cerebrovascular control after transient cerebral ischemia

Philip D. Allan; James Faulkner; Terrence O'Donnell; Jeremy Lanford; Lai-kin Wong; Saqib Saleem; Brandon Woolley; Danielle Lambrick; Lee Stoner; Yu-Chieh Tzeng

doi:10.14814/phy2.12602

Hemodynamic variability and cerebrovascular control after transient cerebral ischemia

Philip D. Allan, James Faulkner, Terrence O'Donnell, Jeremy Lanford, Lai-kin Wong, Saqib Saleem, Brandon Woolley, Danielle Lambrick, Lee Stoner, Yu-Chieh Tzeng

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract We investigated if hemodynamic variability, cerebral blood flow (CBF) regulation, and their interrelationships differ between patients with transient ischemic attack (TIA) and controls. We recorded blood pressure (BP) and bilateral middle cerebral artery flow velocity (MCAv) in a cohort of TIA patients (n = 17), and age-matched controls (n = 15). Spontaneous fluctuations in BP and MCAv were characterized by spectral power analysis, and CBF regulation was assessed by wavelet phase synchronization analysis in the very low- (0.02–0.07 Hz), low- (0.07–0.20 Hz), and high-frequency (0.20–0.40 Hz) ranges. Furthermore, cerebrovascular CO2 reactivity was assessed as a second metric of CBF regulation by inducing hypercapnia with 8 inhalation followed by hyperventilation driven hypocapnia. We found that TIA was associated with higher BP power (group effect, P

Original language	English
Pages (from-to)	e12602
Journal	Physiological Reports
Volume	3
Issue number	11
DOIs	https://doi.org/10.14814/phy2.12602
Publication status	Published - 5 Nov 2015

Keywords

Blood pressure
cerebral blood flow
cerebral hemodynamics
transient ischemic attack
2020

Access to Document

10.14814/phy2.12602

Cite this

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title = "Hemodynamic variability and cerebrovascular control after transient cerebral ischemia",

abstract = "Abstract We investigated if hemodynamic variability, cerebral blood flow (CBF) regulation, and their interrelationships differ between patients with transient ischemic attack (TIA) and controls. We recorded blood pressure (BP) and bilateral middle cerebral artery flow velocity (MCAv) in a cohort of TIA patients (n = 17), and age-matched controls (n = 15). Spontaneous fluctuations in BP and MCAv were characterized by spectral power analysis, and CBF regulation was assessed by wavelet phase synchronization analysis in the very low- (0.02–0.07 Hz), low- (0.07–0.20 Hz), and high-frequency (0.20–0.40 Hz) ranges. Furthermore, cerebrovascular CO2 reactivity was assessed as a second metric of CBF regulation by inducing hypercapnia with 8 inhalation followed by hyperventilation driven hypocapnia. We found that TIA was associated with higher BP power (group effect, P ",

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Hemodynamic variability and cerebrovascular control after transient cerebral ischemia. / Allan, Philip D.; Faulkner, James; O'Donnell, Terrence; Lanford, Jeremy; Wong, Lai-kin; Saleem, Saqib; Woolley, Brandon; Lambrick, Danielle; Stoner, Lee; Tzeng, Yu-Chieh.

In: Physiological Reports, Vol. 3, No. 11, 05.11.2015, p. e12602.

Research output: Contribution to journal › Article › peer-review

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AU - Allan, Philip D.

AU - Faulkner, James

AU - O'Donnell, Terrence

AU - Lanford, Jeremy

AU - Wong, Lai-kin

AU - Saleem, Saqib

AU - Woolley, Brandon

AU - Lambrick, Danielle

AU - Stoner, Lee

AU - Tzeng, Yu-Chieh

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AB - Abstract We investigated if hemodynamic variability, cerebral blood flow (CBF) regulation, and their interrelationships differ between patients with transient ischemic attack (TIA) and controls. We recorded blood pressure (BP) and bilateral middle cerebral artery flow velocity (MCAv) in a cohort of TIA patients (n = 17), and age-matched controls (n = 15). Spontaneous fluctuations in BP and MCAv were characterized by spectral power analysis, and CBF regulation was assessed by wavelet phase synchronization analysis in the very low- (0.02–0.07 Hz), low- (0.07–0.20 Hz), and high-frequency (0.20–0.40 Hz) ranges. Furthermore, cerebrovascular CO2 reactivity was assessed as a second metric of CBF regulation by inducing hypercapnia with 8 inhalation followed by hyperventilation driven hypocapnia. We found that TIA was associated with higher BP power (group effect, P

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