High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial

Garry Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed, Lindsay Bottoms

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Abstract

Background: This study assessed the feasibility and acceptability of two common types of exercise training - high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) - in adults with Crohn's disease (CD). Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews). Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT (288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up. Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].

Original languageEnglish
JournalBMC Gastroenterology
Volume19
Issue number1
DOIs
Publication statusPublished - 29 Jan 2019

Keywords

  • Inflammatory bowel disease
  • Exercise therapy
  • Randomised controlled trial

Cite this

Tew, Garry ; Leighton, Dean ; Carpenter, Roger ; Anderson, Simon ; Langmead, Louise ; Ramage, John ; Faulkner, James ; Coleman, Elizabeth ; Fairhurst, Caroline ; Seed, Michael ; Bottoms, Lindsay. / High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial. In: BMC Gastroenterology. 2019 ; Vol. 19, No. 1.
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abstract = "Background: This study assessed the feasibility and acceptability of two common types of exercise training - high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) - in adults with Crohn's disease (CD). Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews). Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68{\%}) were randomised (47{\%} male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62{\%} for HIIT (288/465) and 75{\%} for MICT (320/429), with 62{\%} of HIIT participants (8/13) and 67{\%} of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97{\%}. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up. Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].",
keywords = "Inflammatory bowel disease, Exercise therapy, Randomised controlled trial",
author = "Garry Tew and Dean Leighton and Roger Carpenter and Simon Anderson and Louise Langmead and John Ramage and James Faulkner and Elizabeth Coleman and Caroline Fairhurst and Michael Seed and Lindsay Bottoms",
year = "2019",
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Tew, G, Leighton, D, Carpenter, R, Anderson, S, Langmead, L, Ramage, J, Faulkner, J, Coleman, E, Fairhurst, C, Seed, M & Bottoms, L 2019, 'High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial' BMC Gastroenterology, vol. 19, no. 1. https://doi.org/10.1186/s12876-019-0936-x

High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial. / Tew, Garry; Leighton, Dean ; Carpenter, Roger; Anderson, Simon; Langmead, Louise; Ramage, John; Faulkner, James; Coleman, Elizabeth ; Fairhurst, Caroline ; Seed, Michael; Bottoms, Lindsay.

In: BMC Gastroenterology, Vol. 19, No. 1, 29.01.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial

AU - Tew, Garry

AU - Leighton, Dean

AU - Carpenter, Roger

AU - Anderson, Simon

AU - Langmead, Louise

AU - Ramage, John

AU - Faulkner, James

AU - Coleman, Elizabeth

AU - Fairhurst, Caroline

AU - Seed, Michael

AU - Bottoms, Lindsay

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Background: This study assessed the feasibility and acceptability of two common types of exercise training - high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) - in adults with Crohn's disease (CD). Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews). Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT (288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up. Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].

AB - Background: This study assessed the feasibility and acceptability of two common types of exercise training - high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) - in adults with Crohn's disease (CD). Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews). Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT (288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up. Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].

KW - Inflammatory bowel disease

KW - Exercise therapy

KW - Randomised controlled trial

U2 - 10.1186/s12876-019-0936-x

DO - 10.1186/s12876-019-0936-x

M3 - Article

VL - 19

JO - BMC Gastroenterology

JF - BMC Gastroenterology

SN - 1471-230X

IS - 1

ER -